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Viagra (Sildenafil Citrate): Side Effects, Interactions ... Viagra (Sildenafil Citrate): Side Effects, Interactions ...
What are the ingredients in VIAGRA? Active ingredient: sildenafil citrate. Inactive ingredients: microcrystalline cellulose, anhydrous dibasic calcium phosphate, ...

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Sildenafil has no direct effect on isolated human corpus cavernosum. The type of adverse reactions in flexible-dose studies, which reflect the recommended dosage regimen, was similar to that for fixed-dose studies. In these studies, involving about 1600 patients, analyses of patient diaries showed no effect of viagra on rates of attempted intercourse (about 2 per week), but there was clear treatment-related improvement in sexual function per patient weekly success rates averaged 1.

Sildenafil should not be used if sexual activity is inadvisable due to underlying cardiovascular risk factors (such as recent sildenafils trade name, viagra, is widely recognized in popular culture, and the drugs association with treating erectile dysfunction has led to its recreational use. Clinical data have shown that co-administration with saquinavir or erythromycin increased plasma levels of sildenafil by about 3 fold see consider a starting dose of 25 mg in patients 65 years, patients with hepatic impairment (e. Health care providers may prescribe generic sildenafil for erectile dysfunction.

Cyp inhibitor, cimetidine, is associated with increased plasma levels of sildenafil see cimetidine (800 mg), a nonspecific cyp inhibitor, caused a 56 increase in plasma sildenafil concentrations when co-administered with viagra (50 mg) to healthy volunteers. Fd & c blue 2 aluminum lake this patient information has been approved by the u. When viagra is co-administered with an alpha-blocker, patients should be stable on alpha-blocker therapy prior to initiating viagra treatment and viagra should be initiated at 25 mg see the recommended dose for ritonavir-treated patients is 25 mg prior to sexual activity and the recommended maximum dose is 25 mg within a 48 hour period because concomitant administration increased the blood levels of sildenafil by 11-fold see consider a starting dose of 25 mg in patients treated with strong cyp3a4 inhibitors (e.

To decrease the chance of adverse reactions in patients taking ritonavir, a decrease in sildenafil dosage is recommended see combination with other pde5 inhibitors or other erectile dysfunction therapies the safety and efficacy of combinations of viagra with other pde5 inhibitors, including revatio or other pulmonary arterial hypertension ( ) treatments containing sildenafil, or other treatments for erectile dysfunction have not been studied. Mean resting values for right atrial pressure, pulmonary artery pressure, pulmonary artery occluded pressure and cardiac output decreased by 28, 28, 20 and 7 respectively. Morriston hospital in swansea, was the first in the world to trial viagra! Boolell m, allen mj, ballard sa, gepi-attee s, muirhead gj, naylor am, osterloh ih, gingell c (june 1996).

If priapism is not treated immediately, penile tissue damage and permanent loss of potency may result see physicians should inform patients not to take viagra with other pde5 inhibitors including revatio or other (pah) treatments containing sildenafil. Sildenafil andor n-desmethylsildenafil, its major active metabolite, may be quantified in plasma, serum, or whole blood to assess pharmacokinetic status in those receiving the drug therapeutically, to confirm the diagnosis in potential poisoning victims, or to assist in the forensic investigation in a case of fatal overdose. Drug interaction effects of the phosphodiesterase 5 inhibitors focus on -blocker interactions.

Table 3 hemodynamic data in patients with stable ischemic heart disease after intravenous administration of 40 mg of sildenafil in a double-blind study, 144 patients with erectile dysfunction and chronic stable limited by exercise, not receiving chronic oral nitrates, were randomized to a single dose of placebo or viagra 100 mg 1 hour prior to exercise testing. This is consistent with ritonavirs marked effects on a broad range of p450 substrates. In volunteers with hepatic impairment (child-pugh class a and b), sildenafil clearance was reduced, resulting in increases in auc (85) and cmax (47) compared to age-matched volunteers with no hepatic impairment. Roger clemens, host of athletes pop viagra to help onfield performance venhuis bj, de kaste d (20062012). Cheitlin, md hutter, am jr brindis, rg ganz, p kaul, s russell, ro jr zusman, rm (15 november 1999).


Sildenafil - Wikipedia


Sildenafil, sold as the brand name Viagra among others, is a medication used to treat erectile dysfunction and pulmonary arterial hypertension. Its effectiveness for treating sexual…

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An FDA investigation has revealed that as many as 25 over-the-counter herbal remedies for erectile dysfunction contain the same active ingredient found in Viagra.
Viagra Active Ingredient Sale Viagra had no effect on ritonavir pharmacokinetics see although the interaction between other protease inhibitors and sildenafil has not been studied, In some of the cases, medical conditions and other factors were reported that may have also played a role in the otologic adverse events. In volunteers with severe renal impairment (clcr 30 mlmin), sildenafil clearance was reduced, resulting in higher plasma exposure of sildenafil (2 fold), approximately doubling of cmax and auc. There have been postmarketing reports of bleeding events in patients who have taken viagra. Due to age-differences in plasma protein binding, the corresponding increase in the auc of free (unbound) sildenafil and its active n-desmethyl metabolite were 45 and 57, respectively see in volunteers with mild (clcr50-80 mlmin) and moderate (clcr30-49 mlmin) renal impairment, the pharmacokinetics of a single oral dose of viagra (50 mg) were not altered. In the nonpregnant rat the auc at this dose was about 20 times human auc.
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    The major circulating metabolite results from n-desmethylation of sildenafil, and is itself further metabolized. Non-arteritic anterior ischemic optic neuropathy (naion), a cause of decreased vision including permanent loss of vision, has been reported rarely post-marketing in temporal association with the use of phosphodiesterase type 5 (pde5) inhibitors, including viagra. The safety and efficacy of viagra with other pde5 inhibitors, including revatio, have not been studied see the use of viagra offers no protection against sexually transmitted diseases. During sexual activity, if you become dizzy or nauseated, or have pain, numbness, or tingling in your chest, arms, neck, or jaw, stop and call your doctor right away. This smooth muscle relaxation leads to vasodilation and increased inflow of blood into the spongy tissue of the penis, causing an erection.

    Healthy elderly volunteers (65 years or over) had a reduced clearance of sildenafil, resulting in approximately 84 and 107 higher plasma auc values of sildenafil and its active n-desmethyl metabolite, respectively, compared to those seen in healthy younger volunteers (18-45 years). Deveci s, pekirciolu l, aygün c, tekin mi, dirim a, ozkarde h (2004). Results with all doses have been pooled, but scores showed greater improvement at the 50 and 100 mg doses than at 25 mg. Viagra (sildenafil citrate) is supplied as blue, film-coated, rounded-diamond-shaped tablets containing sildenafil citrate equivalent to the nominally indicated amount of sildenafil and debossed on the distributed by pfizer labs, division of pfizer inc. Auc and a 42 increase in c max of bosentan (125 mg b.

    An evaluation of visual function at doses up to twice the maximum recommended dose revealed no effects of viagra on viagra is rapidly absorbed after oral administration, with a mean absolute bioavailability of 41 (range 2563). Viagra was effective in a broad range of ed patients, including those with a history of viagra can cause your blood pressure to drop suddenly to an unsafe level if it is taken with certain other medicines. The results suggest an approximate 2 fold increase in the risk of naion within 5 half-lives of pde5 inhibitor use. In these two subjects, hypotension was reported as a moderately severe adverse event, beginning at approximately 1 hour after administration of viagra 50 mg and resolving after approximately 7. In the titration studies (n644) (with most patients eventually receiving 100 mg), results were similar. In 1994, pfizer filed a patent covering the use of sildenafil to treat erectile dysfunction. A total dose of 40 mg sildenafil was administered by four intravenous infusions. Many of these events were reported to occur during or shortly after sexual activity, and a few were reported to occur shortly after the use of viagra without sexual activity. It is not possible to determine whether these reported events are related directly to the use of viagra, to the patients underlying risk factors for hearing loss, a combination of these factors, or to other factors see , temporary vision lossdecreased vision, ocular redness or bloodshot appearance, ocular burning, ocular swellingpressure, increased , retinal edema, retinal vascular disease or bleeding, and vitreous tractiondetachment. In addition to the active ingredient, sildenafil citrate, each tablet contains the following inactive ingredients microcrystalline cellulose, anhydrous dibasic calcium phosphate, croscarmellose sodium, magnesium stearate, hypromellose, titanium dioxide, lactose, triacetin, and fd & c blue 2 aluminum lake.

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